https://www.ceesdekker.net Secrets

Rotary motion of DNA rotors on nanopores. Prime row: raw video with the Cy5 channel of each rotor. Center row: corresponding single-particle localization effects of the two finishes in the DNA rotors. The position of the present body is marked as orange and blue dots, as well as the trajectory of The ten frames ahead of the current frame is revealed as sound lines.

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Multicolor imaging on the bacterial nucleoid and mobile division proteins with blue, orange, and close to-infrared fluorescent proteins

2007, first genuine-time detection of strand exchange in homologous recombination by RecA; discovery of a minimal persistence length of ends of microtubules; and resolved the system of biosensing with carbon nanotubes

2015, discovery that condensin is often a hugely flexible protein composition; and 1st detection of DNA knots utilizing nanopores

SMC complexes can pass Actual physical roadblocks larger than their ring measurement, indicating a nontopological mechanism for DNA loop extrusion

Size control of person carbon nanotubes by nanostructuring Using the scanning tunneling microscope

Instance (1) of bending configurations in 3D simulations of https://www.ceesdekker.net DNA rods on nanopores. A part of the membrane is demonstrated in gray, the rim from the pore is highlighted in crimson, and also a 3D rendering of your motion from the DNA rod is shown.

The rotors harness Power from the nanoscale drinking water and ion flow that may be produced by a static chemical or electrochemical possible gradient during the nanopore, that happen to be set up via a salt gradient or utilized voltage, respectively. These synthetic nanoengines self-Arrange and operate autonomously in physiological ailments, suggesting strategies to developing Vitality-transducing motors at nanoscale interfaces.

Resolving the step size in condensin-pushed DNA loop extrusion identifies ATP binding given that the action-making course of action

An built-in microfluidic System for quantifying drug permeation across biomimetic vesicle membranes

Lots of new phenomena have been found, and he and his investigate group founded a leading posture On this field of investigation. Dekker and his study team discovered new physics of nanotubes together with explored the feasibility of molecular electronics. In 1998, they had been the 1st to construct a transistor based upon just one nanotube molecule.

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2013, managed shaping of Reside bacterial cells into arbitrary styles; and discovery of spontaneous fluctuations within the handedness of histone tetrasomes

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